Anniyan is the story of Ramanujam Ambi Iyengar (Vikram), a lawyer who suffers from Multiple Personality Disorder. Ambi is an innocent and honest lawyer. If he comes across anyone not obeying the rules he files cases against them but all his efforts go in vain. His constant habit to be perfect in rules and honesty leads him to develop a Multiple Personality Disorder in which a new character in him grows as Anniyan (Vikram) and starts a website called to hear people's complaints. The new character, Anniyan, is a violent man. When he is Ambi and comes across a person who does not obey rules he makes complaints in his website. When he is Anniyan, he goes and kills them by methods used for torturing people in hell. He apparently takes the definition of these methods from the Garuda Purana.
在录像带店工作的店员艾德（马修·麦康纳 Matthew McConaughey 饰）是一个普通的不能再普通的三十岁男人，就连他自己也想象不到，有一天，自己竟然成为了家喻户晓的电视名人。原来，电视台节目总监辛西娅（艾伦·德詹尼丝 Ellen DeGeneres 饰）的事业遭遇了滑铁卢，日渐低迷的收视率让她的职位受到了巨大的威胁，在这个节骨眼上，她决定制作一档二十四小时连续放送的大型真人秀节目，而节目的主人公正是艾德。 很快，艾德的名字便响彻了大江南北，名声和利益接踵而至，让一向不引人注目的艾德尝尽了一夜成名的梦幻滋味。然而，随着时间的推移，艾德发现自己的出名带来的并不只是美好的一面，渐渐显露出的贪婪的人心和无处不在的监视和束缚让他开始想要回到曾经简单快乐自由自在的生活中去。