故事发生在十七世纪的西班牙，阿拉特里斯德（维果·莫特森 Viggo Mortensen 饰）是誉满全国的军队上尉，同时亦是巴尔博亚（尤纳克斯·乌高德 Unax Ugalde 饰）的监护人。阿拉特里斯德希望能够将巴尔博亚培养成为和自己一样孔武有力的真正的男子汉，然而巴尔博亚却爱上了名为安杰丽卡（埃琳纳·安娜亚 Elena Anaya 饰）的危险女子，这令阿拉特里斯德忧心忡忡，因为安杰丽卡的父亲路易斯（Jesús Castejón 饰）和自己曾经有过一段恩怨。

四个手无寸铁的女人，一场夺命的富贵奇谋，安娜为了摆脱困苦的生活，下嫁于墨西哥毒贩头子，并搬迁到墨西哥生活。尽管丈夫日进斗金，却常常对她拳打脚踢，终于，愤怒的安娜纠集了此前的姐妹，四女子打算展开一场既能复仇，又可富贵的计划。

Amazon rainforest, 1538. King Carlos V de España y I de Alemania sends a group of Spanish soldiers to the new continent to locate Teziutlan, a legendary city created with gold, to claim it to the Spanish Empire. Alone in the rainforest and without a help, soldiers face not only indigenous tribes but the manifest hate themselves by their respective birth places. Leaded by old Don Gonzalo, married with young Doña Ana, his aging and weak health turns in danger Ana, who is disputed by Alférez Gorriamendi, Gonzalo's right-hand, and soldier Martín Dávila. After to realize that Viceroy of Port Prince has send another expedition looking for them leaded by Juan Medrano after to accuse Don Gonzalo of treason, Dávila, Gorriamendi and other soldiers as Sargento Bastaurrés and Barbate must decide if fight against Medrano's and his men or continue until Teziutlan. But the rivalry and hate between them will reveal more dangerous than the own rainforest and the indigenous tribes